Sir Arthur Conan Doyle's first novel-and the origin story of Sherlock Holmes and John Watson-is reimagined in the first unabridged, fully illustrated version since its debut, by acclaimed and bestselling illustrator Gris Grimly. The year is 1881. The city, London. A man lies dead in an empty house, not a mark upon him, and no clues-save for the word "RACHE" scrawled in blood on the wall above. Elsewhere, two men-a former army doctor called John Watson and a brilliant eccentric called Sherlock Holmes-meet for the first time. These two events set in motion an adventure into the darkest corners of men's hearts as the cold, calculating investigative methods of Mr. Holmes are put to the test in a case that spans decades and continents, rife with danger and intrigue. Originally published in 1887, A Study in Scarlet was the first novel to feature a character whose name would become synonymous with the art of deduction. Today it is completely reimagined with artwork by the m...
Development of New Radical Cascades and Multi-Component Reactions : Application to the Synthesis of Nitrogen-Containing Heterocycles (9783319377865)
In this dissertation, Marie-Helene Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals.The clarity and depth of the experimental section will be useful for students and researchers working in this field.
Product details
- Paperback | 326 pages
- 155 x 235 x 18.54mm | 718g
- 23 Sep 2016
- Springer International Publishing AG
- Cham, Switzerland
- English
- Softcover reprint of the original 1st ed. 2014
- 42 Illustrations, color; 475 Illustrations, black and white; XXII, 326 p. 517 illus., 42 illus. in color.
- 3319377868
- 9783319377865
Download Development of New Radical Cascades and Multi-Component Reactions : Application to the Synthesis of Nitrogen-Containing Heterocycles (9783319377865).pdf, available at ebookdownloadfree.co for free.
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